Enhanced chlorhexidine skin penetration with 1,8-cineole
نویسندگان
چکیده
منابع مشابه
Enhanced chlorhexidine skin penetration with 1,8-cineole
BACKGROUND Chlorhexidine (CHG) penetrates poorly into skin. The purpose of this study was to compare the depth of CHG skin permeation from solutions containing either 2% (w/v) CHG and 70% (v/v) isopropyl alcohol (IPA) or 2% (w/v) CHG, 70% (v/v) IPA and 2% (v/v) 1,8-cineole. METHODS An ex-vivo study using Franz diffusion cells was carried out. Full thickness human skin was mounted onto the cel...
متن کاملEnhanced chlorhexidine skin penetration with eucalyptus oil
BACKGROUND Chlorhexidine digluconate (CHG) is a widely used skin antiseptic, however it poorly penetrates the skin, limiting its efficacy against microorganisms residing beneath the surface layers of skin. The aim of the current study was to improve the delivery of chlorhexidine digluconate (CHG) when used as a skin antiseptic. METHOD Chlorhexidine was applied to the surface of donor skin and...
متن کاملPenetration of chlorhexidine into human skin.
This study evaluated a model of skin permeation to determine the depth of delivery of chlorhexidine into full-thickness excised human skin following topical application of 2% (wt/vol) aqueous chlorhexidine digluconate. Skin permeation studies were performed on full-thickness human skin using Franz diffusion cells with exposure to chlorhexidine for 2 min, 30 min, and 24 h. The concentration of c...
متن کاملPathways for Skin Penetration
This paper reviews recent fi ndings about three skin penetration pathways (including a “polar pathway”) and four types of penetration enhancers (enzymes, vesicular systems, ceramides and chemical enhancers). This article will review possible ways for compounds to penetrate the skin and interact with it. Four families of enhancers will be discussed, along with their possible mechanisms of action...
متن کاملIn vitro skin penetration measurement with contrast-enhanced MRI at 7 Tesla
Methods: Penetration studies according to OECD guidelines [1] were performed using skin samples taken from porcine ear. For enhancing the transport of the contrast agent into the skin a submicron emulsion containing 1mmol/ml Gadolinium (Gadobutrol, Gadovist, Schering, Germany) was used. The experiments were performed using the Franz-Diffusion-Cell setup, a standard device for in vitro penetrati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2017
ISSN: 1471-2334
DOI: 10.1186/s12879-017-2451-4